{"id":746,"date":"2021-03-08T15:08:00","date_gmt":"2021-03-08T23:08:00","guid":{"rendered":"https:\/\/info.pediatricsdirectory.com\/?p=746"},"modified":"2023-08-27T15:34:26","modified_gmt":"2023-08-27T19:34:26","slug":"short-course-antimicrobial-therapy-for-pediatric-community-acquired-pneumonia-the-safer-randomized-clinical-trial","status":"publish","type":"post","link":"https:\/\/pediatricscommunity.com\/info\/746\/","title":{"rendered":"Abx for pneumonia"},"content":{"rendered":"\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" loading=\"lazy\" width=\"1024\" height=\"717\" src=\"https:\/\/pediatricscommunity.com\/info\/wp-content\/uploads\/2023\/07\/one_line_mothers_day_baby-7-01-scaled-1-1024x717.jpg\" alt=\"\" class=\"wp-image-5243\" srcset=\"https:\/\/pediatricscommunity.com\/info\/wp-content\/uploads\/2023\/07\/one_line_mothers_day_baby-7-01-scaled-1-1024x717.jpg 1024w, https:\/\/pediatricscommunity.com\/info\/wp-content\/uploads\/2023\/07\/one_line_mothers_day_baby-7-01-scaled-1-300x210.jpg 300w, https:\/\/pediatricscommunity.com\/info\/wp-content\/uploads\/2023\/07\/one_line_mothers_day_baby-7-01-scaled-1-768x538.jpg 768w, https:\/\/pediatricscommunity.com\/info\/wp-content\/uploads\/2023\/07\/one_line_mothers_day_baby-7-01-scaled-1-1536x1075.jpg 1536w, https:\/\/pediatricscommunity.com\/info\/wp-content\/uploads\/2023\/07\/one_line_mothers_day_baby-7-01-scaled-1-2048x1434.jpg 2048w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h4 class=\"wp-block-heading\">Short-Course Antimicrobial Therapy for Pediatric Community-Acquired Pneumonia: The SAFER Randomized Clinical Trial<\/h4>\n\n\n\n<p><strong>Objective.<\/strong>&nbsp;&nbsp;To determine whether 5 days of high-dose amoxicillin for CAP was associated with noninferior rates of clinical cure compared with 10 days of high-dose amoxicillin.<\/p>\n\n\n\n<p><strong>Interventions<\/strong>.&nbsp;&nbsp;Five days of high-dose amoxicillin therapy followed by 5 days of placebo (intervention group) vs 5 days of high-dose amoxicillin followed by a different formulation of 5 days of high-dose amoxicillin (control group).<\/p>\n\n\n\n<p><strong>Results<\/strong>.\u00a0\u00a0Among the 281 participants, the median age was 2.6 (interquartile range, 1.6-4.9) years. Clinical cure at 14 to 21 days was observed in 108 of 126 (85.7%) in the intervention group and in 106 of 126 (84.1%) in the control group in the intention-to-treat analysis (risk difference, 0.023; 97.5% confidence limit, \u22120.061). Clinical practice guidelines should consider recommending 5 days of amoxicillin for pediatric pneumonia management in accordance with antimicrobial stewardship principles.<\/p>\n\n\n\n<p><strong>FULL SOURCE:<\/strong> <a href=\"https:\/\/jamanetwork.com\/journals\/jamapediatrics\/article-abstract\/2776976?guestAccessKey=2d4f8d66-1a94-4081-a59e-529fb018c8db&amp;utm_source=silverchair&amp;utm_medium=email&amp;utm_campaign=article_alert-jamapediatrics&amp;utm_content=etoc&amp;utm_term=050321\">JAMA Pediatrics<\/a><\/p>\n<span class=\"tags-links\"><a href=\"https:\/\/pediatricscommunity.com\/info\/amoxicillin\/\" rel=\"tag\">amoxicillin<\/a><a href=\"https:\/\/pediatricscommunity.com\/info\/antibiotic-utilization\/\" rel=\"tag\">antibiotic utilization<\/a><a href=\"https:\/\/pediatricscommunity.com\/info\/community-acquired-pneumonia\/\" rel=\"tag\">community-acquired pneumonia<\/a><a href=\"https:\/\/pediatricscommunity.com\/info\/safer\/\" rel=\"tag\">SAFER<\/a><\/span>","protected":false},"excerpt":{"rendered":"<p>Short-Course Antimicrobial Therapy for Pediatric Community-Acquired Pneumonia: The SAFER Randomized Clinical Trial Objective.&nbsp;&nbsp;To determine whether 5 days of high-dose amoxicillin for CAP was associated with noninferior rates of clinical cure compared with 10 days of high-dose amoxicillin. Interventions.&nbsp;&nbsp;Five days of high-dose amoxicillin therapy followed by 5 days of placebo (intervention group) vs 5 days of [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false},"categories":[274],"tags":[506,524,792,1823],"_links":{"self":[{"href":"https:\/\/pediatricscommunity.com\/info\/wp-json\/wp\/v2\/posts\/746"}],"collection":[{"href":"https:\/\/pediatricscommunity.com\/info\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pediatricscommunity.com\/info\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pediatricscommunity.com\/info\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/pediatricscommunity.com\/info\/wp-json\/wp\/v2\/comments?post=746"}],"version-history":[{"count":5,"href":"https:\/\/pediatricscommunity.com\/info\/wp-json\/wp\/v2\/posts\/746\/revisions"}],"predecessor-version":[{"id":5721,"href":"https:\/\/pediatricscommunity.com\/info\/wp-json\/wp\/v2\/posts\/746\/revisions\/5721"}],"wp:attachment":[{"href":"https:\/\/pediatricscommunity.com\/info\/wp-json\/wp\/v2\/media?parent=746"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pediatricscommunity.com\/info\/wp-json\/wp\/v2\/categories?post=746"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pediatricscommunity.com\/info\/wp-json\/wp\/v2\/tags?post=746"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}