{"id":456,"date":"2021-11-25T08:50:42","date_gmt":"2021-11-25T16:50:42","guid":{"rendered":"https:\/\/info.pediatricsdirectory.com\/?p=456"},"modified":"2021-11-25T08:50:42","modified_gmt":"2021-11-25T16:50:42","slug":"il-17-cytokines-in-psoriasis","status":"publish","type":"post","link":"https:\/\/pediatricscommunity.com\/info\/456\/","title":{"rendered":"IL-17 cytokines in psoriasis"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Abstract<\/h2>\n\n\n\n<p>Psoriasis is a chronic inflammatory skin condition associated with immune dysregulation. The immunologic cascade mediated by the interleukin (IL)-17 pathway plays a critically important role in the pathogenesis of psoriasis. The IL-17 effectors (IL-17A, IL-17C, IL-17E, and IL17F) act on keratinocytes, endothelial cells, and immune cells to stimulate epidermal hyperplasia and the pro-inflammatory feed-forward cycle seen within plaque psoriasis. The IL-17 pathway is also hypothesized to modulate the inflammatory responses linking co-morbid systemic diseases with psoriasis. <\/p>\n\n\n\n<p>Furthermore, the robust clinical response seen with <span class=\"highlighter\">current and emerging therapies targeting IL-17<\/span> emphasizes the importance of the IL-17 cytokines in the pathogenesis of psoriasis.<\/p>\n\n\n\n<p><strong>SOURCE:<\/strong> <a href=\"https:\/\/www.dovepress.com\/the-role-of-il-17-cytokines-in-psoriasis-peer-reviewed-fulltext-article-ITT\">ImmunoTargets and Therapy<\/a><\/p>\n<span class=\"tags-links\"><a href=\"https:\/\/pediatricscommunity.com\/info\/biologics\/\" rel=\"tag\">biologics<\/a><a href=\"https:\/\/pediatricscommunity.com\/info\/cytokines\/\" rel=\"tag\">cytokines<\/a><a href=\"https:\/\/pediatricscommunity.com\/info\/il-17\/\" rel=\"tag\">IL-17<\/a><a href=\"https:\/\/pediatricscommunity.com\/info\/interleukins\/\" rel=\"tag\">interleukins<\/a><a href=\"https:\/\/pediatricscommunity.com\/info\/psoriasis\/\" rel=\"tag\">psoriasis<\/a><a href=\"https:\/\/pediatricscommunity.com\/info\/secukinumab\/\" rel=\"tag\">secukinumab<\/a><\/span>","protected":false},"excerpt":{"rendered":"<p>Abstract Psoriasis is a chronic inflammatory skin condition associated with immune dysregulation. The immunologic cascade mediated by the interleukin (IL)-17 pathway plays a critically important role in the pathogenesis of psoriasis. The IL-17 effectors (IL-17A, IL-17C, IL-17E, and IL17F) act on keratinocytes, endothelial cells, and immune cells to stimulate epidermal hyperplasia and the pro-inflammatory feed-forward [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false},"categories":[135,211],"tags":[616,852,1252,1295,1738,1853],"_links":{"self":[{"href":"https:\/\/pediatricscommunity.com\/info\/wp-json\/wp\/v2\/posts\/456"}],"collection":[{"href":"https:\/\/pediatricscommunity.com\/info\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pediatricscommunity.com\/info\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pediatricscommunity.com\/info\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/pediatricscommunity.com\/info\/wp-json\/wp\/v2\/comments?post=456"}],"version-history":[{"count":0,"href":"https:\/\/pediatricscommunity.com\/info\/wp-json\/wp\/v2\/posts\/456\/revisions"}],"wp:attachment":[{"href":"https:\/\/pediatricscommunity.com\/info\/wp-json\/wp\/v2\/media?parent=456"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pediatricscommunity.com\/info\/wp-json\/wp\/v2\/categories?post=456"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pediatricscommunity.com\/info\/wp-json\/wp\/v2\/tags?post=456"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}