To study characteristics of oxygenation during the first two postnatal months and correlation with the occurrence and severity of retinopathy of prematurity (ROP) among infants of extremely low birth weight. Severe ROP is associated with greater FiO₂ exposure, increased iatrogenic hyperoxemia, decreased ambient air hyperoxemia, and increased hypoxemia in infants of extremely low birth weight despite a greater frequency of FiO₂ titration. This study illustrates the need for automated closed loop FiO₂ delivery systems to further optimize oxygen saturation targeting in this high-risk population. SOURCE: Journal of Pediatrics