OPEN CLINICAL STUDY (Calgary): Human Milk-derived Fortification in Preterm Infants

Recent advances in lacto-engineering techniques allowed the manufacturing of multi-nutrient HMF from human milk as an alternative to bovine milk. Since exposure to infant bovine-based formula feeds is frequently shown to increase neonatal morbidities, human milk-derived HMFs (H-HMFs) have been frequently proposed to minimize exposure to bovine products prior to 34 weeks gestation with an intent to decrease the risks of necrotizing enterocolitis and feeding intolerance. The use of multi-nutrient H-HMFs is a promising intervention however currently available H-HMFs are expensive.

The main objective of this randomized controlled trial is to compare the weight gain achieved by preterm infants born <1250 g and fed human milk fortified with H-HMFs made from mother’s own milk (MOM) when MOM supply exceeds the daily need of her preterm infant, or from donor human milk (DHM), compared with counterparts fed human milk fortified with the currently used bovine-derived fortifier (B-HMF).

MORE INFO: ClinicalTrials.gov